Sign In
Register
eISSN:2278-5299

International Journal of Latest Research in Science and Technology

DOI:10.29111/ijlrst   ISRA Impact Factor:3.35

A News Letter Sign UP!
Modeling and Simulation Study of Electrochemical Sensor for Glucose Concentration Measurement in Clinical Diagnosis

Open Access

International Journal of Latest Research in Science and Technology Vol.11 Issue 1, pp 1-5,Year 2022

MODELING AND SIMULATION STUDY OF ELECTROCHEMICAL SENSOR FOR GLUCOSE CONCENTRATION MEASUREMENT IN CLINICAL DIAGNOSIS

Babatunde S. Emmanuel, Stella A. Emmanuel

Correspondence should be addressed to :

Received : 25 January 2022; Accepted : 08 February 2022 ; Published : 10 March 2022

Share
Download 0
View 7
Article No. 11028
Abstract

This paper presents the modeling and simulation study of an electrochemical blood glucose sensor for clinical diagnosis. The working principle of the proposed sensing device is based on amperometry, that is, the measurement of electric current from a chemical reaction process. An applied voltage to the working and reference electrodes of the sensor resulted in the oxidation of glucose in the analyte sample, and the current due to this oxidation is measured at the electrode. As the input glucose concentration increases from 0.1M to 0.9M in the modeled glucose biosensor, the output response in terms of average current density increases linearly from 0.75 A/m2 to 7.8 A/m2. The linearity of response is a desirable property for an efficient measurement system.

Key Words   
Electrochemical, sensor, glucose, amperometry, diagnosis
Acknowledgement
The authors gratefully acknowledge the management of the Lead City University, Ibadan and the Chemistry Advanced Research Centre, SHESTCO, Abuja, Nigeria for the support and facilities provided for the successful completion of this research project.
Copyright
References
  1. Faridbod, V. K. Gupta, and H. A. Zamani (2011) Electrochemical Sensors and Biosensors. International Journal of Electrochemistry, 2011, 1–2. doi:10.4061/2011/352546 
  2. Sridara, J. Upan, G. Saianand, A. Tuantranont, C. Karuwan, and J. Jakmunee (2020). Non-Enzymatic Amperometric Glucose Sensor Based on Carbon Nanodots and Copper Oxide Nanocomposites Electrode. Sensors, 20(3), 808. doi:10.3390/s20030808 
  3. Thunkhamrak, P. Chuntib, K. Ounnunkad, P. Banet, P.H. Aubert, G. Saianand, A.I. Gopalan, J. Jakmunee (2020) Highly sensitive voltammetric immunosensor for the detection of prostate specific antigen based on silver nanoprobe assisted graphene oxide modified screen printed carbon electrode. Talanta, 208, 120389.
  4. S. Paik, Y. R. Kim, H. G. Hong (2018) Amperometric Glucose Biosensor Utilizing Zinc Oxide-chitosan-glucose Oxidase Hybrid Composite Films on Electrodeposited Pt-Fe(III). Anal Sci. 2018;34(11):1271-1276. doi: 10.2116/analsci.18P054. PMID: 30416185.
  5. Pinyou, A. Ruff, S. Pöller, S. Barwe, M. Nebel, N. G. Alburquerque, E. Wischerhoff, A. Laschewsky, S. Schmaderer, J. Szeponik, N. Plumeré, W. Schuhmann (2015) Thermoresponsive amperometric glucose biosensor. Biointerphases. 2015 Mar 24;11(1):011001. doi: 10.1116/1.4938382. PMID: 26702635.
  6. B. Rakhi, P. Nayak, C. Xia, H. N. Alshareef (2016) Novel amperometric glucose biosensor based on MXene nanocomposite. Sci Rep. 2016 Nov 10;6:36422. doi: 10.1038/srep36422. Erratum in: Sci Rep. 2016 Dec 09;6:38465. PMID: 27830757; PMCID: PMC5103228.
  7. Liu, L. Shi, W. Niu, H. Li and G. Xu (2008) Amperometric glucose biosensor based on single-walled carbon nanohorns. Biosensors and Bioelectronics, 23(12), 1887–1890. doi:10.1016/j.bios.2008.02.016
  8. S. Kucherenko, D. Y. Didukh, O. O. Soldatkin, A. P. Soldatkin (2014) Amperometric biosensor system for simultaneous determination of adenosine-5'-triphosphate and glucose. Anal Chem. 2014 Jun 3;86(11):5455-62. doi: 10.1021/ac5006553. Epub 2014 May 21. PMID: 24810180.
  9. N. Kotanen, C. Tlili, A. Guiseppi-Elie (2013) Amperometric glucose biosensor based on electroconductive hydrogels. Talanta. 2013 Jan 15;103:228-35. doi: 10.1016/j.talanta.2012.10.037. Epub 2012 Nov 1. PMID: 23200382.
  10. F. Ang, L. Y. Por, M. F. Yam (2015) Development of an amperometric-based glucose biosensor to measure the glucose content of fruit. PLoS One. 2015 Mar 19;10(3):e0111859. doi: 10.1371/journal.pone.0111859. PMID: 25789757; PMCID: PMC4366129.
  11. Xiang, L. Yin, J. Ma, E. Guo, Q. Li, Z. Li, K. Liu (2015) Amperometric hydrogen peroxide and glucose biosensor based on NiFe2/ordered mesoporous carbon nanocomposites. Analyst. 2015 Jan 21;140(2):644-53. doi: 10.1039/c4an01549e. PMID: 25429370.
  12. C. Cebedio, L. A. Rabioglio, I. E. Gelosi, R. A. Ribas, A. J. Uriz, and J. C. Moreira (2020). Analysis and Design of a Microwave Coplanar Sensor for Non-Invasive Blood Glucose Measurements. IEEE Sensors Journal, 20(18), 10572–10581. doi:10.1109/jsen.2020.2993182 
  13. Kim, K. Adhikari, R. Dhakal, Z. Chuluunbaatar, C. Wang, and E.-S. Kim (2015) Rapid, sensitive, and reusable detection of glucose by a robust radiofrequency integrated passive device biosensor chip,” Rapid, sensitive, and reusable detection of glucose by a robust radiofrequency integrated passive device biosensor chip, vol. 5, 01 2015.
  14. Topsakal, T. Karacolak, and E. C. Moreland, (2011) Glucose-dependent dielectric properties of blood plasma,” in 2011 XXXth URSI General Assembly and Scientific Symposium, Aug 2011, pp. 1–4.
  15. Yilmaz, R. Foster, and Y. Hao (2019) Radio-frequency and microwave techniques for non-invasive measurement of blood glucose levels, Diagnostics, vol. 9, no. 1, 2019.
  16. Strakosas, J. Selberg, P. Pansodtee, N. Yonas, P. Manapongpun, M. Teodorescu, and M. Rolandi, (2019) A non-enzymatic glucose biosensor enabled by bioelectronic pH control,” Science Reports, vol. 9,7 pages, Jul. 2019.
  17. Prickril and A. Rasooly (Eds) (2017) Biosensors and Biodetection Methods and Protocols: Electrochemical, Bioelectronic, Piezoelectric, Cellular and Molecular Biosensors; Volume 2; Second Edition; Humana Press; Methods in Molecular Biology 11572; Springer Protocols; p. vii.
  18. H. Yoo, and Lee, S. Y. (2010). Glucose Biosensors: An Overview of Use in Clinical Practice. Sensors, 10(5), 4558–4576. doi:10.3390/s100504558 
  19. Arslan and U. Beskan (2013) An amperometric biosensor for glucose detection from glucose oxidase immobilized in polyaniline–polyvinylsulfonate–potassium ferricyanide film. Artificial Cells, Nanomedicine, and Biotechnology, 42(4), 284–288. doi:10.3109/21691401.2013.812650
  20. Amarandei, E. Ungureanu, M. Leonida and C. Andronescu (2012) Glucose oxidase "wired" with potassium ferricyanide polypyrrole films; U.P.B. Sci. Bull., Series B, Vol. 74, Iss. 3, 2012
  21. Amor-Gutiérrez, E. Costa-Rama, and M. T. Fernández Abedul (2020) Determination of glucose with an enzymatic paper-based sensor. Laboratory Methods in Dynamic Electroanalysis, 257–265. doi:10.1016/b978-0-12-815932-3.00025-5 
  22. Wang (2008) Electrochemical Glucose Biosensors. Chemical Reviews, 108(2), 814–825. doi:10.1021/cr068123a
To cite this article

Babatunde S. Emmanuel, Stella A. Emmanuel , " Modeling And Simulation Study Of Electrochemical Sensor For Glucose Concentration Measurement In Clinical Diagnosis ", International Journal of Latest Research in Science and Technology . Vol. 11, Issue 1, pp 1-5 , 2022

Responsive image

MNK Publication was founded in 2012 to upholder revolutionary ideas that would advance the research and practice of business and management. Today, we comply with to advance fresh thinking in latest scientific fields where we think we can make a real difference and growth now also including medical and social care, education,management and engineering.

Responsive image

We offers several opportunities for partnership and tie-up with individual, corporate and organizational level. We are working on the open access platform. Editors, authors, readers, librarians and conference organizer can work together. We are giving open opportunities to all. Our team is always willing to work and collaborate to promote open access publication.

Responsive image

Our Journals provide one of the strongest International open access platform for research communities. Our conference proceeding services provide conference organizers a privileged platform for publishing extended conference papers as journal publications. It is deliberated to disseminate scientific research and to establish long term International collaborations and partnerships with academic communities and conference organizers.