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International Journal of Latest Research in Science and Technology

DOI:10.29111/ijlrst   ISRA Impact Factor:3.35

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The ubiquitination of KCTD12 in S phase promotes the formation of breast cancer

Open Access

International Journal of Latest Research in Science and Technology Vol.9 Issue 2, pp 18-21,Year 2020

THE UBIQUITINATION OF KCTD12 IN S PHASE PROMOTES THE FORMATION OF BREAST CANCER

Ying Zhong *, Dongling Zhang , Huifeng Li

Correspondence should be addressed to :

Received : 17 April 2020; Accepted : 28 April 2020 ; Published : 30 April 2020

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Article No. 10990
Abstract

In order to study the role of KCTD12 in breast cancer, the tissue microarray and bioinformatics methods were used. At the same time, in vitro we used MDA-MB-231 a cell line of breast cancer to research the influence of KCTD12 on breast cancer cells, the ability of proliferation and colony formation of 231 which with over expression KCTD12 were detected. At last we used the method of synchronization preliminary to discusse the mechanism of KCTD12 regulated the cell cycle and promoted the formation of breast cancer. We found that KCTD12 was highly expressed in breast cancer tissues and that patients with high KCTD12 expression had low survival rate. At the same time, in vitro experiments also confirmed that KCTD12 promoted cell proliferation and enhanced the ability of cell colony formation. Meanwhile, by means of synchronization, we found that KCTD12 was ubiquitination in S phase, which may be the reason for its regulation of cell cycle.

Key Words   
KCTD12, breast cancer, ubiquitination, S phase, tumorigenesis

Acknowledgement
This study was supported by Medical research fund project of guangdong province(A2018185)
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References
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To cite this article

Ying Zhong *, Dongling Zhang , Huifeng Li , " The Ubiquitination Of Kctd12 In S Phase Promotes The Formation Of Breast Cancer ", International Journal of Latest Research in Science and Technology . Vol. 9, Issue 2, pp 18-21 , 2020

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