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International Journal of Latest Research in Science and Technology

DOI:10.29111/ijlrst   ISRA Impact Factor:3.35

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NEUROTOXICOLOGICAL EFFECT OF STEROIDAL DERIVATIVES IN CHANGES OF CHOLESTEROL LEVEL IN DIFFERENT REGIONS OF ALBINO RAT BRAIN

Research Paper Open Access

International Journal of Latest Research in Science and Technology Vol.8 Issue 1, pp 5-7,Year 2019

NEUROTOXICOLOGICAL EFFECT OF STEROIDAL DERIVATIVES IN CHANGES OF CHOLESTEROL LEVEL IN DIFFERENT REGIONS OF ALBINO RAT BRAIN

Sheeba Shafi

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Received : 13 February 2019; Accepted : 19 February 2019 ; Published : 28 February 2019

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Abstract

Changes in the level of cholesterol in albino rat brain ( Cerebrum hemisphere , Cerebellum and brain stem were evaluated following the administration of four steroidal derivatives as 3β-acetoxy-5-bromo-6β-Hydoxy-5α cholestane A( I ), 3β-Acetoxy-6-dimethyl amino cholest -5-ene B (II ), 3β-Chloro –5-bromo-6 β-nitro-5α-cholestane C ( III ) and 6 β-Amino pyrimidino-cholest-4 -ene -3-one D ( IV ).Experiments were carried out on four groups of six male albino rat weight 200 ± 20 g. Controlled rats were administered normal saline water intraperitonially (i.p ) while the other experimental group were given 0.3 mg/ kg body weight of steroidal solution ,which was prepared in the peanut oil .

Key Words   
cholesterol, cerebrum, cerebellum and brain stem

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To cite this article

Sheeba Shafi , " Neurotoxicological Effect Of Steroidal Derivatives In Changes Of Cholesterol Level In Different Regions Of Albino Rat Brain ", International Journal of Latest Research in Science and Technology . Vol. 8, Issue 1, pp 5-7 , 2019

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