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International Journal of Latest Research in Science and Technology

DOI:10.29111/ijlrst   ISRA Impact Factor:3.35

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COMPARATIVE STUDY OF EFFICACY AMONG TOCILIZUMAB, ETANERCEPT AND DISEASE MODIFYING DRUGS IN COMBINATION WITH METHOTREXATE: A SINGLE CENTER STUDY FROM LANZHOU, CHINA

Research Paper Open Access

International Journal of Latest Research in Science and Technology Vol.8 Issue 1, pp 1-4,Year 2019

COMPARATIVE STUDY OF EFFICACY AMONG TOCILIZUMAB, ETANERCEPT AND DISEASE MODIFYING DRUGS IN COMBINATION WITH METHOTREXATE: A SINGLE CENTER STUDY FROM LANZHOU, CHINA

Manisha Bhochhibhoya, Shen Haili , Binit Vaidya

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Received : 12 February 2019; Accepted : 20 February 2019 ; Published : 28 February 2019

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Abstract

Purpose: The study aims to evaluate and compare the disease activities in Rheumatoid arthritis (RA) patients treated with MTX in combination with the conventional synthetic disease modifying antirheumatic drugs (csDMARD), Etanercept (ETC) and Tocilizumab (TCZ). Method: This was a prospective cohort study of patients with RA maintained at Second Hospital of Lanzhou University, Lanzhou from March 2016 to December 2018.Patients meeting criteria were grouped into three groups: group 1 treated with csDMARDs in combination with MTX (n=51), group 2 ETC in combination with MTX 2(n=49) and group 3 with TCZ in combination with MTX (n=50). Result: Of total patients (N=150), females were 72% (108/150) and the mean age at presentation was 43.3±9.9 years, 40.6±14.2 years, 38.2±14.7 years in group 1, 2 and 3 respectively. Baseline erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) of group 3 were statistically higher than group 1 and not different from group 2. The mean disease activity score (DAS) 28-ESR of group 1, 2 and 3 were 4.6±1.01, 4.9±0.91 and 5.3±2.0 respectively at baseline and 0.45±0.8, 0.57±0.89 and 2.16±1.5 respectively at 3months (p<0.001). The group 3 patients even though had higher baseline activity, there was a significant improvement in all parameters after 3 months as compared to other groups. Conclusion: TCZ in combination with MTX can be a good therapeutic option in treating moderate to severe RA compared to csDMARDs and ETC.

Key Words   
Rheumatoid Arthritis, Tocilizumab, Disease Activity, Interleukin-6 Inhibitor
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To cite this article

Manisha Bhochhibhoya, Shen Haili , Binit Vaidya , " Comparative Study Of Efficacy Among Tocilizumab, Etanercept And Disease Modifying Drugs In Combination With Methotrexate: A Single Center Study From Lanzhou, China ", International Journal of Latest Research in Science and Technology . Vol. 8, Issue 1, pp 1-4 , 2019

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