Postoperative cognitive dysfunction (POCD) is a common multifactorial adverse event frequently in elderly patients. POCD diagnosis usually demands a long neuropsychological battery and specific professional for evaluate the results data as a neuropsychologist. As a tentative to overcome that issue, Mental Plus® video game was developed as a tool to assess cognitive function and future rehabilitation. The primary study objective was MentalPlus® reliability evaluation to assess cognition in healthy volunteers. METHODS: 163 volunteers were randomized to play MentalPlus® versions A and B with a week interval between both moments. Mini-Mental State Examination was applied to assess the volunteers mental state, and we excluded those with scores below 18 or 23 related to a determined educational level. MentalPlus® applicability and reproducibility were evaluated by kappa index and McNemar test. RESULTS: The patients had mean age of 36±16 years; 46 % male; School level mean of 5±2 years, the mean income of 4.6± 3 Brazilian minimum wage and the Mini-Mental score of 28±3, for an expectation of more than 25±3. The MentalPlus® A and B versions results revealed the subsequent kappa coefficients for reliability tests. For general cognitive function, kappa coefficient was 0.7122 (p<0.005); selective attention and alternating attention presented 0.4004 and 0.3998 (p<0.005); long-term memory and inhibitory control had comparable coefficients: 0.4103 and 0.4406 (p<0.005); executive function disclosed a kappa coefficient of 0.4406, through construct inhibitory control. The expected cognitive function scores in MentalPlus® were expressed as a mean and standard deviation and confidence interval of 95%, α=0.05. MentalPlus® versions A and B values were similar when comparing with values adopted by researchers. CONCLUSION: MentalPlus® digital game presented reliable evidence for cognition evaluation. It might be a future accessible tool for POCD evaluation and probable future rehabilitation. Trial registration: www.clinicaltrials.gov Identifier: NCT02551952.