Gerard Piel (1915-2004), scientific editor of the life science magazine, once wrote, “Without publication, science is dead”. It explains the importance of publication of findings in scientific journals so that other scientists working in the field know about new findings. If after conducting an investigation, the research is not published and outcome is not shared, the data would have no meaning for investigators and other scientists. Such a scenario fits well with the saying “Publish or Perish”; if the findings are not published then investigators will be perished since their work will not receive any recognition. It is therefore, sharing the knowledge through paper writing and publication is important. Writing paper is not an easy job; it requires skills, knowledge and patience that stress out people, specially young investigators. In the present paper, we brought methods, skills, techniques and information required to write an effective paper, specially for those who have just started their career in science and those who are in the middle of their scientific career as investigators, professor, scientists etc. The present paper will also help investigators to write their papers, which may not have English as their native language. We have made every effort to include in this paper as much information as possible to write effective scientific papers that journals take seriously.