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eISSN:2278-5299

International Journal of Latest Research in Science and Technology

DOI:10.29111/ijlrst   ISRA Impact Factor:3.35

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PARKIN, PARKINSON DISEASE GENE PRODUCT, DIRECTLY REDUCES HYDROGEN PEROXIDE (MITOCHONDRIAL OXIDANT), AND FORMS DIMERIZATION REVERSIBLY.

Research Paper Open Access

International Journal of Latest Research in Science and Technology Vol.5 Issue 4, pp 1-3,Year 2016

PARKIN, PARKINSON DISEASE GENE PRODUCT, DIRECTLY REDUCES HYDROGEN PEROXIDE (MITOCHONDRIAL OXIDANT), AND FORMS DIMERIZATION REVERSIBLY.

Tohru Kitada ,Rie Hikita, Hideo Hirose

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Received : 01 July 2016; Accepted : 21 July 2016 ; Published : 31 August 2016

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Article No. 10665
Abstract

The current central dogma of Parkin function is that the E3 ligase Parkin ubiquitinates its substrate on the surface of damaged mitochondria and removes them to maintain mitochondrial quality. However, recent pathological and biochemical evidence confirmed that Parkin has a protective function from oxidative stress, especially in mitochondria. The relationship between the two hypotheses has not yet been clear. In this short report, we show; First, Parkin reacts with H2O2 directly and reduces it, and turns into Parkin dimer. Furthermore, supplied antioxidant changes dimer into monomer again. These suggest that Parkin is also a redox molecule in mitochondria as well as E3 ligase outside mitochondria.

Key Words   
Parkin, PINK1, DJ-1, Familial Parkinson’s Disease, Mitochondria, Oxidative Stress, E3 Ligase, Hydr
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References
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To cite this article

Tohru Kitada ,Rie Hikita, Hideo Hirose , " Parkin, Parkinson Disease Gene Product, Directly Reduces Hydrogen Peroxide (mitochondrial Oxidant), And Forms Dimerization Reversibly. ", International Journal of Latest Research in Science and Technology . Vol. 5, Issue 4, pp 1-3 , 2016

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