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International Journal of Latest Research in Science and Technology

DOI:10.29111/ijlrst   ISRA Impact Factor:3.35

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EVALUATION OF IN VIVO HEALING AND ANGIOGENIC EFFECTS OF GELS CONTAINING SCHINUS TEREBINTHIFOLIUS RADDI EXTRACT ON OPEN WOUNDS

Research Paper Open Access

International Journal of Latest Research in Science and Technology Vol.4 Issue 4, pp 145-150,Year 2015

EVALUATION OF IN VIVO HEALING AND ANGIOGENIC EFFECTS OF GELS CONTAINING SCHINUS TEREBINTHIFOLIUS RADDI EXTRACT ON OPEN WOUNDS

Jaleska Santos Olinto Trindade, Kalline Alves de Araújo, João Carlos da Silva, Ciro Dantas Soares, Cypriano Galvão da Trindade Neto, Eduardo Pereir

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Received : 17 August 2015; Accepted : 25 August 2015 ; Published : 31 August 2015

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Article No. 10557
Abstract

Objective: To assess the healing and angiogenic effects of SchinusterebinthifoliusRaddi (STR) extract embedded in chitosan and Carbopol® gels in an experimental model using Wistar rats. Methods: Fifteen Wistar rats (mean age, 90 ± 15 days; weight, 270 ± 70 g) were subjected to a skin wound model and were then divided into three groups of 5 rats each based on the topical treatment received: CG (control group), sodium chloride (NaCl) 0.9%; CTE, treated with chitosan gel containing STR extract once per day; and CPE, treated with Carbopol® gel containing STR extract once per day. A morphometric analysis was performed on the first and seventh days of treatment. After euthanasia, an excisional biopsy was performed for histological and histomorphometric analysis. Results: The qualitative microscopic analysis revealed that there was increased angiogenesis and elevation in the number of fibroblasts and collagen in the CTE group compared with the other groups. Conclusion: In the present in vivo study, chitosan gel with STR extract repaired wounds more effectively than NaCl solution or Carbopol® formulation, with greater amounts of collagen and more angiogenesis stimulation.

Key Words   
Wound healing, Schinus,Anacardiaceae, Angiogenesis, Chitosan

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To cite this article

Jaleska Santos Olinto Trindade, Kalline Alves de Araújo, João Carlos da Silva, Ciro Dantas Soares, Cypriano Galvão da Trindade Neto, Eduardo Pereir , " Evaluation Of In Vivo Healing And Angiogenic Effects Of Gels Containing Schinus Terebinthifolius Raddi Extract On Open Wounds ", International Journal of Latest Research in Science and Technology . Vol. 4, Issue 4, pp 145-150 , 2015

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