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International Journal of Latest Research in Science and Technology

DOI:10.29111/ijlrst   ISRA Impact Factor:3.35

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COMPUTATIONAL DRUG RE-POSITIONING: AN APPROACH TO DISCOVER NOVEL ANTIMALARIALS

Research Paper Open Access

International Journal of Latest Research in Science and Technology Vol.4 Issue 4, pp 119-127,Year 2015

COMPUTATIONAL DRUG RE-POSITIONING: AN APPROACH TO DISCOVER NOVEL ANTIMALARIALS

Yunusa, Abdulmajeed,Bello, shaibu Oricha,Chika, Aminu

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Received : 20 August 2015; Accepted : 25 August 2015 ; Published : 31 August 2015

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Abstract

In this study molecular docking method was used to select potential inhibitors of the Plasmodium targets and the antimalarial activity of these inhibitors (drugs) was confirmed using Plasmodium berghei induced mice (in vivo). One hundred commercially available drugs not used for malaria were selected from DrugBank and the potential binding affinities of the selected drugs against the Plasmodium targets were analysed using molegro virtual docker software. Ten drugs with the best affinities (Fluconazole, indomethacin, loratidine, lisinopril, meloxicam, promethazine, nifedipine, clarithromycin, piroxicam and flucloxacillin) were selected and the antimalarial activity of these drugs were confirmed using Plasmodium berghei mice model. Nifedipine, clarithromycin, flucloxacillin and lisinopril produced significant suppressive, curative and prophylactic activity while meloxicam and piroxicam produced only significant suppressive and curative activity. All the tested drugs produced significant suppressive activity. Nifedipine, clarithromycin, flucloxacillin and lisinopril are therefore potential chemoprophylatic and chemothrerapeutic agents whilemeloxicam and piroxicam are potential chemotherapeutic agents.

Key Words   
Plasmodium berghei, Antimalarial, Computational repositioning;Mice.

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To cite this article

Yunusa, Abdulmajeed,Bello, shaibu Oricha,Chika, Aminu , " Computational Drug Re-positioning: An Approach To Discover Novel Antimalarials ", International Journal of Latest Research in Science and Technology . Vol. 4, Issue 4, pp 119-127 , 2015

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