Sign In
Register
eISSN:2278-5299

International Journal of Latest Research in Science and Technology

DOI:10.29111/ijlrst   ISRA Impact Factor:3.35

A News Letter Sign UP!
SYNTHESIS, CHARACTERIZATION AND APPLICATION OF NANOMATERIALS BASED ON NOBLE METALLIC NANOPARTICLES AND ANTHOCYANINS

Research Paper Open Access

International Journal of Latest Research in Science and Technology Vol.4 Issue 2, pp 16-22,Year 2015

SYNTHESIS, CHARACTERIZATION AND APPLICATION OF NANOMATERIALS BASED ON NOBLE METALLIC NANOPARTICLES AND ANTHOCYANINS

Liliana Olenic,Ioana Chiorean

Correspondence should be addressed to :

Received : 05 April 2015; Accepted : 11 April 2015 ; Published : 30 April 2015

Share
Download 125
View 182
Article No. 10483
Abstract

Natural extracts from European Cornel fruits have been found to be a significant source of natural antioxidants with health benefits for human body. In the present work we focused on using these extracts for preparing new nanomaterials based on metallic nanoparticles, taking in consideration that these metals have been used for a long time as treatment in medical fields. We have developed a synthesis method which permits to obtain the noble metal nanoparticles having anthocyanins from natural extract as ligands. We have characterized them by UV-Vis spectroscopy, Transmission Electron Microscopy (TEM), Dynamic Light Scattering (DLS), X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC). Equilibrium constants of reactions between gold/silver nanoparticles and organic molecules as ligands have been determined in two ways and have been found of 104 orders of magnitude, values that suggest a good association between them. Some new medical products (creams) based on gold/silver-natural extracts have been applied on skin lesions appeared due to the psoriatic illness. The creams prepared have been used on a lot of 31 human subjects with skin lesions and after two months of treatment, a good anti-inflammatory effect has been observed. The good medical results have been confirmed by statistical studies

Key Words   
Nanomaterials, Colloids, Binding Constants Determination

Copyright
References
  1. N. Chen, S. C. Chu, H. L. Chiou, W. H. Kuo, C. L Chiang,. Y. S. Hsieh, “Mulberry anthocyanins, cyaniding 3-rutinoside and cyanidin 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line,” Cancer Lett. 235, pp. 248-259, 2006.
  2. J. Awika, W. L. Rooney and D. R. Waniska, “Anthocyanins from black sorghum and their antioxidant properties,” Food Chem. 90, pp. 293-301, 2004.
  3. Mattivi, R. Guzzon, U. Vrhovsek, M. Stefanini and R. J. Velasco, “Metabolite profiling of grape: flavonols and anthocyanins,” Agric. Food Chem. 54, pp. 7692-7702, 2006.
  4. V. Filimon, D. Beceanu, M. Niculaua, C. Arion, “Study on the anthocyanin content of some sour cherry varieties grown in Iasi, Romania,” Agronomical Research in Moldavia XLIV, 1, 145, pp. 81-91, 2011.
  5. E. Lohse, N. D. Burrows, L. Scarabelli, L. M. Liz-Marzan, C.J. Murphy, “Anisotropic Noble Metal Nanocrystal Growth: The Role of Halides,” Chem. Mater. 26, pp. 34-43, 2014.
  6. Ingham, T. H. Lim, C. J. Dotzler, A. Henning, M. F. Toney and R. D. Tilley, “How nanoparticles coalesce-An in situ study of Au nanoparticle aggregation and grain growth,” Chem. Mater. 23, pp. 3312-3317, 2011.
  7. Sardar, A. M. Funston, P. Mulvaney and R. W. Murray, “Gold Nanoparticles: Past, Present, and Future”, Langmuir 25, pp. 13840–13851, 2009.
  8. J. Mieszawska, J. M. Mulder, Z. A. Fayad and D. P. Cormode, “Multifunctional gold nanoparticles for diagnosis and therapy of disease,” Mol. Pharmaceutics 10, pp. 831-847, 2013.
  9. S. Thakor, J. Jokerst, C. Zavaleta, T. F. Massoud, S. Gambhir, “Gold nanoparticles: a revival in precious metal administration to patients,” Nano Lett. 11, pp. 4029-4036, 2011.
  10. V. Bonifacio, P. Bento da Silva,  M. Aparecido dos Santos Ramos, K. M. Silveira Negri,  T. M. Bauab and M. Chorilli, “Nanotechnology-based drug delivery systems and herbal medicines: a review,” Int. J. Nanomedicine, 9, pp. 1-15, 2014.
  11. Ankamwar, C. Damle, A. Ahmad, M. J. Sastry, ”Biosynthesis of gold and silver nanoparticles using Emblica Officinalis fruit extract, their phase transfer and Transmetallation in an organic solution,” Nanosci. Nanotechno. 5, pp. 1665-1671, 2005.
  12. Krisch, L. Galgoczy, M. Tolgyesi, T. Papp and C. Vagvolgyi,” Effect of fruit juices and pomace extracts on the growth of Gram-positive and Gram-negative bacteria,” Acta Biol. Szeged 52, pp. 267-270, 2008.
  13. Ghodake, C.-Y. Eom, S. Wouk Kim and E. Jin, “Biogenic nano-synthesis; towards the efficient production of the biocompatible gold nanoparticle,” Bull. Korean Chem. Soc. 31, pp. 2771-2775, 2010.
  14. P. Dubey, M. Lahtinen and M. Sillanpea, “Tansy fruit mediated greener synthesis of silver and gold nanoparticles,” Process. Biochem. 45, pp. 1065-1071, 2010.
  15. Chauhan, M. Kumar Upadhyay, N. Rishi and S. Rishi, “Phytofabrication of silver nanoparticles using pomegrate fruit seeds,” Int. J. Nanomater. Bios. 1, pp. 17-21, 2011.
  16. S. Kavitha, S. Baker, D. Rakshith, H. U. Kavitha, H. C. Yashwantha Rao, B. P. Harini and S. I. Satish, “Plants as Green Source towards Synthesis of Nanoparticles,” Res. J. Biological Sci. 2, pp. 66-76, 2013.
  17. Kumar Das, S. Kaur Brar, “Plant mediated green synthesis: modified approaches,” Nanoscale 5, pp. 10155-10162, 2013.
  18. K. Santos, M. H. Oyafuso, C. P. Kiill, M. P. D. Gremiao and M. Chorilli, “Nanotechnology-based drug delivery systems for treatment of hyperproliferative skin diseases – a review,” Curr. Nanosci. 9, pp. 159-167, 2013.
  19. T. Kim Thanh, “Functional nanoparticles for biomedical applications,” Nanoscale, 5, pp. 11338-11338, 2013.
  20. Hudoklin, D. Zupancic, D. Makovec, M. Erdani Kreft and R. Romih, “Gold nanoparticles as physiological markers of urine internalization into urothelial cells in vivo,” Int. J. Nanomedicine, 8, pp. 3945-3953, 2013.
  21. Xiang, Y. Zheng, W. Duan, X. Li, J. Yin, S. Shigdar, M. Liam O’Connor, M. Marappan, X. Zhao, Y. Miao, B. Xiang and C. Zheng, “Inhibition of A/Human/Hubei/3/2005 (H3N2) influenza virus infection by silver nanoparticles in vitro and in vivo,” Int. J. Nanomedicine 8, pp. 4103-4114, 2013.
  22. Verma and S. P. Singh, “Current and future status of herbal medicines,” Vet World, 1, pp. 347-350, 2008.
  23. He, Z. Du, H. Lv, Q. Jia, Z. Tang, X. Zheng and K. Zhang, “Green synthesis of silver nanoparticles by Chrysanthemum morifolium Ramat extract and their application in clinical ultrasound gel,” Int J Nanomedicine 8, pp. 1809-1815, 2013.
  24. S. Akhtar, J. Panwar and Y-S. Yun, “Biogenic synthesis of metallic nanoparticles by plant extracts,” ACS Sustainable Chem. Eng. 1, pp. 591-602, 2013.
  25. L. Fox, “Silver sulfadiazine--a new topical therapy for Pseudomonas in burns. Therapy of Pseudomonas infection in burns,” Arch. Surg., 96, pp. 184-188, 1968.
  26. Shrivastava, T. Bera, S. K. Singh, G. Singh, P. Ramachandrarao and D. Dash, “Characterization of antiplatelet properties of silver nanoparticles,” ACS Nano 3, pp. 1357-1364, 2009.
  27. C. Daniel and D. Astruc, “Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties and application toward biology, cathalysis and nanothechnology,” Chem.Rev. 104, pp. 293-330, 2004.
  28. H. Dinolfo and J. T. Hupp, ”Supramolecular coordination chemistry and functional microporous molecular materials,” Chem. Mater. 13, pp. 3113-3125, 2001.
  29. Ivask, A.El Badawy, C. Kaweeteerawat, D. Boren, H. Fischer, Z. Ji, C. H. Chang, R. Liu, T. Tolaymat, D. Telesca, J. I. Zink, Y. Cohen, P. A. Holden and H. A. Godwin, “Toxicity mechanisms in Esterichia coli vary for silver nanoparticles and differ from ionic silver,” Nano, 8, pp. 374-386, 2014.
  30. J. Klimenko, “The cornelian cherry (Cornus mas L.): collection, preservation, and utilization of genetic resources,” Fruit Ornam. Plant. Res. 12, pp. 92-98, 2004
  31. Gunduz, O. Saracoglu, M. Ozgen and S. Serce, “Antioxidant, Physical and Chemical Characteristics of Cornelian Cherry Fruits (Cornus mas L.) at different Stages of Ripeness,” Acta Sci. Pol. Hortorum Cultus 12, pp. 59-66, 2013.
  32. Polinicencu, H. Popescu and C. Nistor, “Vegetal extracts for cosmetic use: Extracts from fruits of Cornus mas. Preparation and characterization,” Clujul Medical, 53, pp. 160-163, 1980.
  33. E. Pantelidis, M. Vasilakakis, G. A. Manganaris and Gr. Diamantidis, “Antioxidant capacity, phenol, anthocyanin and ascorbic acid contents in raspberries, blackberries, red currants, gooseberries and Cornelian cherries,” Food Chem., 102, pp. 777-783, 2007.
  34. Crisan, L. David, B. Moldovan, A. Vulcu, S. Dreve, M. Perde-Schrepler, C. Tatomir, A. G. Filip, P. Bolfa, M. Achim, I. Chiorean, I. Kacso, C.  Berghian Grosan and L.Olenic, “New nanomaterials for the improvement of psoriatic lesions,” J. Mater. Chem. B, 1, pp. 3152-3158, 2013.
  35. Olenic L., Vulcu A., Chiorean I., Crisan M., Berghian-Grosan C., Dreve S., David L., Tudoran L. B., Kacso I., Bratu I., Neamtu C., Voica C., “Effect of Natural Extracts pH on Morphological Characteristics of Hybrid Materials Based on Gold Nanoparticles,” AIP Conf Proc PIM Cluj-Napoca, Romania, pp. 1565, 238-242, 2013.
  36. Moldovan, O. Ghic, L. David and C. Chisbora, “The influence of storage on the total phenols contente and antioxidant activity of the Cranberrybush (Viburnum opulus L) fruits extract,” Rev. Chim. Bucharest, 63, pp. 463-464, 2012.
  37. M. Giusti, L. E. Rodriguez-Saona and R. E. Wrolstad, “Molar absorbtivity and color characteristics of acylated and non-acylated pelargonidin-based anthocyanins,” J. Agric. Food Chem., 47, pp. 4631-4637, 1999
  38. A. Benesi and J. H. A Hildebrand, “Spectrophotometry of iodine with Aromatic hydrocarbons,” J. Am. Chem. Soc., 71, 8, pp. 2703-2707, 1949.
  39. George Thomas, J. Zajicek and P. V. Kamat, “Surface binding properties of tetraoctylammonium Bromide-capped gold nanoparticles,” Langmuir, 18, pp. 3722-3727, 2002.
  40. Frens, “Controlled Nucleation for the Regulation of the Particle Size in monodisperse Gold Suspensions,” Nat. Phys. Sci., 241, pp. 20-22, 1973.
  41. Siyam Ansar, R. Haputhanthri, B. Edmonds, D. Liu, L. Yu, A. Sygula and D. J. Zhang, “Determination of the Binding Affinity, Packing, and Conformation of Thiolate and Thione Ligands on Gold Nanoparticles,” Phys. Chem. C, 115, pp. 653-660, 2011.
  42. Mihailescu, L. Olenic, S. Pruneanu, I. Bratu and I.Kacso, “The effect of pH on amino acids binding to gold nanoparticles,” J. Optoelectron. Adv. Mater. 9, pp. 756-759, 2007.
  43. Sopousek, J. Bursik, J. Zalesak and Z. Pesina, “Silver nanoparticles sintering at low temperature on a copper substrate: In Situ characterisation under inert atmosphere and air,” J. Min. Metall. Sect. B-Metall. B, 48, pp. 63-71, 2012.
  44. J. Coutts, M. B. Cortie, M. J. Ford and A. M. McDonagh, “Rapid and Controllable Sintering of Gold Nanoparticle Inks at RoomTemperature Using a Chemical Agent,” J. Phys. Chem. C 113, pp. 1325-1328, 2009.
  45. K. Volkman, S. Yin, T. Bakhishev, K. Puntambekar, V. Subramanian and F. M. Toney, “Mechanistic Studies on Sintering of Silver Nanoparticles,” Chem. Mater., 23, pp. 4634-4640, 2011.
  46. Yang, www.nanomastech.com, Nanoparticle Inks for Printed Electronics-nanoparticles.org/pdf.
To cite this article

Liliana Olenic,Ioana Chiorean , " Synthesis, Characterization And Application Of Nanomaterials Based On Noble Metallic Nanoparticles And Anthocyanins ", International Journal of Latest Research in Science and Technology . Vol. 4, Issue 2, pp 16-22 , 2015

Responsive image

MNK Publication was founded in 2012 to upholder revolutionary ideas that would advance the research and practice of business and management. Today, we comply with to advance fresh thinking in latest scientific fields where we think we can make a real difference and growth now also including medical and social care, education,management and engineering.

Responsive image

We offers several opportunities for partnership and tie-up with individual, corporate and organizational level. We are working on the open access platform. Editors, authors, readers, librarians and conference organizer can work together. We are giving open opportunities to all. Our team is always willing to work and collaborate to promote open access publication.

Responsive image

Our Journals provide one of the strongest International open access platform for research communities. Our conference proceeding services provide conference organizers a privileged platform for publishing extended conference papers as journal publications. It is deliberated to disseminate scientific research and to establish long term International collaborations and partnerships with academic communities and conference organizers.