Sign In
Register
eISSN:2278-5299

International Journal of Latest Research in Science and Technology

DOI:10.29111/ijlrst   ISRA Impact Factor:3.35

A News Letter Sign UP!
THE EFFECT OF CAMPHOR (CINNAMOMUM CAMPHORA) ON CONCENTRATION OF LIVER ENZYMES IN FEMALE RATS

Research Paper Open Access

International Journal of Latest Research in Science and Technology Vol.4 Issue 1, pp 111-113,Year 2015

THE EFFECT OF CAMPHOR (CINNAMOMUM CAMPHORA) ON CONCENTRATION OF LIVER ENZYMES IN FEMALE RATS

Maryam Abedini,Habibollah Johari, Syamak Fallahi

Correspondence should be addressed to :

Received : 19 February 2015; Accepted : 26 February 2015 ; Published : 28 February 2015

Share
Download 125
View 182
Article No. 10472
Abstract

ALT and AST are two important enzymes in liver that high level of them indicates liver damage. There are some factors that cause increase in these enzymes in blood such as drugs or diseases. Camphor as a herbal medicine is used for its effects on reproductive system, kidney, liver, aborting etc. In this research we have examined the effect of camphor on concentration of enzymes in liver. 40 female rats with average weight 180 ± 20 gram and age 80-90 days are used. They are divided into 5 groups randomly. The control group received no injection. The sham group received olive oil as camphor solvent. The experimental groups 1, 2 and 3 received camphor solution in doses of 25, 50 and 100 mg/kg. Daily injection was done intraperitioneally and amount 0.2 cc. All of them received drug for 14 days. At the end of the injections a sample of serum was taken and was examined by Eliza method in order to determine the concentration of enzymes. The results showed no significant difference between control group and examined groups. Although there were no significant differences but it showed an increase in amount of enzymes in experimental groups compared to control. Maybe by using camphor in higher doses it leads to significant increase in concentration of enzymes. So it suggests that camphor has an stimulating effect on liver enzymes.

Key Words   
camphor, liver, enzyme, rat

Copyright
References
  1. Enaibe, B., Eweka, A and Adjene, J. “Toxicological effects of camphor administration on the histology of the kidney of the rabbit (Oryctolagus cuniculus).” Int J Toxicol, Vol. 5, No. 2, 2007.
  2. Jadhav, M.V., Sharma, R.C., Rathore Mansee and Gangawane, A.K. “Effect of cinnamomum camphora on human sperm motility and sperm viability.” Journal of Clinical Research Letters, Vol. 1, No.1, pp. 1-10, 2010.
  3. Thomas, L. “Alanine aminotransferase (ALT), Aspartate aminotransferase (AST).” In: Thomas L, editor. Clinical Laboratory Diagnostics. 1st ed.Frankfurt: TH-Books verlagsgesellschaft , pp. 55-65, 1998.
  4. Moss, D.W and Henderson, A.R. “Clinical enzymology.” In:Burtis CA, Ashwood ER, editor. Tiets textbook of Clinical Chemistry.3rd ed. Philadelphia: W.B Saunders Company, pp. 617-721, 1999.
  5. Singh, P., Srivastava, B., Kumar, A and Dubey, N.K. “Fungal contamination of raw materials of some herbal drugs and recommendation of cinnamomum camphora oil as herbal fungi toxicant.” Microb Ecol. Vol. 56, No. 3, pp.555-560, 2008.
  6. 6- Giaccio, M. “Crocetin from saffron: An active component of an ancient spice.”  Crit Rev Food Sci Nutr. Vol. 44, No. 3, pp. 155-72, 2004.
  7. 7- Adjene, J.O and Enaibe, B.U. “Histological studies of the teratogenic effects of camphor on the developing liver of the Wistar rats.” Annals Biomedical Sciences. Vol. 1, No. 2, pp. 88-93, 2002.
  8. 8- Hye, L., Eun-A H., Weon, J.Y., Byung, H.K., Man, H.R. Hee, K.K, et al. “ In vitro anti-inflammatory and anti-oxidative effects of Cinnamomum camphora extracts.” J Ethnopharmacol .Vol. 103, pp. 208-216, 2005.
  9. 9- Gyoubu, K and Miyazawa, M. “In vitro metabolism of (-)-camphor using human liver microsomes and CYP2A6.” Biol Pharm Bull. Vol. 30, No. 2, pp. 2230-3, 2007.
  10. 10- Ashby, J., Tinwell, H., Odum, J and Lefere P. “Natural variability and the influence of concurrent control values on the detection and interpretation of low dose or weak endocrine toxicities.” Environ Health Perspect . Vol. 112, No. 8, pp. 847-853, 2004.
  11. 11- Kmrakova, M., Sehmisch, S., Tezval, M., Schmelz, U., Frauendorf, H., Grueger T, et al. Impact of 4-methylbenzylidene camphor, diadzein and estrogen on intact and osteomized bone in osteopenic rats. J Endocrinol. Vol. 211, pp. 157-168, 2011.
  12. 12- Komarkova, M., Werner, C., Wicke, M., Nguyen, B.T., Sehmisch, S., Tezval, M, et al. “Effect of daidzein, 4-methylbenzylidene camphor or estrogen on gastrocnemius muscle of osteoporotic rats undergoing tibia healing period. J Endocrinol . Vol. 201, No. 2, pp. 253-262, 2009.
  13. 13- Siegel, E and Wason, S. “Camphor toxicity.pediatric clinics of North America.” National Poison Center .Vol. 33, pp.375-379, 1986.
  14. 14- Shahabi, S., Jorsaraei, S., Moghadamnia, A., Barghi, E., Zabihi, E., Golsorkhtabar Amini M, et al. “The effects of camphor on sex hormones levels in rats.” Cell J. Vol. 16, No. 2, pp. 231-234, 2014.
  15. 15- Tung, Y.T., Huang, C.C., Ho, S.T., Kuo, Y.H,. Lin, C.C. Lin, C.T, et al. “ Bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum prevent lipopolysaccharid/D-galactosamine (LPS/D-GalN)-induced acute hepatitis in mice.” J Agric Food Chem . Vol.59, No. 15, pp. 8117-23, 2011.
  16. 16- Drotman, R and Lawhan, G. “ Serum enzymes are indication of chemical induced liver damage.” Drug Chem Toxicol . Vol.1, No. 2, pp. 163-71, 1978.
  17. 17- Aliye, U.C., Warren, P Bishop., Kathleen, D Sanders. “Camphor Hepatotoxicity.” South Med J. Vol. 93, No. 6, 2000.
  18. 18- Mereto, E., Brambilla-Campart, G., Ghia, M., Martelli, A and Brambilla, G. “ Cinnamaldehyde-induced micronuclei in rodent liver.” Mutat Res . Vol. 322, No. 1, pp.1-8, 1994.
  19. 19- Muguruma, M., Moto, M., Sasaki, Y.F. Okamura, M., Watanabe, T., Kashida, Y, et al. “Absence of DNA damage in Comet assay liver initiation activity of Cinnamaldehyde.” J Toxicol Pathol . Vol.18, No. 1, pp. 27, 2005.
  20. 20- Kunz, P.Y., Gries, T., Fent, K. “The uv filter 3-benzylidene camphor adversely affects reproduction in fathead minnow (Pimephales promelas).” Toxicology Sciences, Vol. 93, No. 2, pp.311-321, 2006.
  21. 21- Maria, E.C., Osvaldo, J.P., Romina , P., Berta, S., Maria, L.D. Reynoso , R . “Low dose 4-MBC effect on neuroendocrine regulation of reproductive axis in adult male rats.” Environ Toxicol Pharmacol Vol. 26, No. 2, pp. 222-224, 2008.
  22. 22- Ryszka, F., Dolinska, B., Slawski, M., Orkisz, w. “Effect of prolactin on release of selected enzymes from the isolated rabbit liver.” Transplant Proc, Vol. 36, No. 9, pp. 2583-5, 2004.
  23. 23- Dolinska, B., Budzinski, G., Caban, A., Ostrozka-Cieslik, A., Oczkowicz, G., Cierpka L, et al. “Prolactin (PRL) reduces the release of transaminases from the isolated pig liver.” Ann Transplant.  16, No. 2, pp. 98-102, 2011.
  24. 24- Linjawi, S.A. “Effect of camphor on uterus histology of pregnant rats.” The Journal of King Abdulaziz University-Medical Sciences, Vol. 16, No. 2, pp. 77-90, 2009.
  25. 25- Banerjee, S., Welsch, C.W.,  Rao, A.R. “Modulatory influence of camphor on the activities of hepatic carcinogen metabolizing enzymes and the levels of hepatic and extra hepatic reduced glutathione in mice.” Cancer Lett, Vol. 88, No. 2, pp. 163-9, 1995.
To cite this article

Maryam Abedini,Habibollah Johari, Syamak Fallahi , " The Effect Of Camphor (cinnamomum Camphora) On Concentration Of Liver Enzymes In Female Rats ", International Journal of Latest Research in Science and Technology . Vol. 4, Issue 1, pp 111-113 , 2015

Responsive image

MNK Publication was founded in 2012 to upholder revolutionary ideas that would advance the research and practice of business and management. Today, we comply with to advance fresh thinking in latest scientific fields where we think we can make a real difference and growth now also including medical and social care, education,management and engineering.

Responsive image

We offers several opportunities for partnership and tie-up with individual, corporate and organizational level. We are working on the open access platform. Editors, authors, readers, librarians and conference organizer can work together. We are giving open opportunities to all. Our team is always willing to work and collaborate to promote open access publication.

Responsive image

Our Journals provide one of the strongest International open access platform for research communities. Our conference proceeding services provide conference organizers a privileged platform for publishing extended conference papers as journal publications. It is deliberated to disseminate scientific research and to establish long term International collaborations and partnerships with academic communities and conference organizers.