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International Journal of Latest Research in Science and Technology

DOI:10.29111/ijlrst   ISRA Impact Factor:3.35

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COULD GRAPE SEED EXTRACT MODULATES NEPHRITIC DAMAGE INDUCED BY METHOMEX IN MALE RATS?

Research Paper Open Access

International Journal of Latest Research in Science and Technology Vol.2 Issue 5, pp 26-31,Year 2013

COULD GRAPE SEED EXTRACT MODULATES NEPHRITIC DAMAGE INDUCED BY METHOMEX IN MALE RATS?

Amal Attia El-Morsy Ibrahim

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Received : 22 October 2013; Accepted : 27 October 2013 ; Published : 31 October 2013

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Abstract

Methomex (Metho) is classified as a carbamate insecticide. The present study was designed to examine the influence of grape seed oil (GSO) on the histopathological changes in Methomex-induced kidney in male rats. Rats were divided into 6 groups, the first of which was considered as control. The 2nd group was treated with 4 ml/kgGSO. Rats from 3rd and 4th groups treated with Metho at level doses 2.4 mg/kg and 4.8 mg/kg. Rats from 5th and 6th groups pre-administered with GSO then treated with 2.4 and 4.8 mg/kg Metho. Metho administration caused destruction of the normal pattern of the renal tissue. These damages were encountered by the presence some glomeruli appeared atrophy with distension of Bowman’s space and degeneration of their parietal epithelial cells. The lumina of distal and proximal convoluted tubules contain hyaline casts of dead cells. The renal medulla showed dilated collecting tubules stuffed with R.B.Cs. Pre-administration of GSO to Metho-induced rats, revealed apparent normal renal parenchyma. The proximal convoluted tubules and collecting tubules appeared near to normal with their narrow lumen. Pre-administration with GSO exhibited that it has a protective effect against Methomex-induced toxic effects in the kidney. The present study advocated using GSO in the daily diets.

Key Words   
Grape seed oil - Methomex – Kidney - Histopathology

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To cite this article

Amal Attia El-Morsy Ibrahim , " Could Grape Seed Extract Modulates Nephritic Damage Induced By Methomex In Male Rats? ", International Journal of Latest Research in Science and Technology . Vol. 2, Issue 5, pp 26-31 , 2013

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